One Health is a collaborative, multisectoral, and transdisciplinary approach—working at the local, regional, national, and global levels—with the goal of achieving optimal health outcomes recognizing the interconnection between people, animals, plants, and their shared environment. EPA’s Office of Research and Development (ORD) has been partnering with the Association of Fish and Wildlife Agencies (AFWA), the Association of State and Territorial Health Officials (ASTHO), and the Environmental Council of the States (ECOS) to raise awareness of One Health.